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While this rapid evolution toward multi-agonist strategies and oral formulations promises enhanced efficacy, tolerability, and adherence, generating robust long-term safety and efficacy evidence remains imperative

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Selank administration had no effect on the behavior of the C57Bl/6 mice while producing a significant anxiolytic impact on the BALB/c mice due to Selanks protective action on enkephalins [5]

Indeed, while in rats exposed to alcohol without BPC 157 administration, more pronounced edema of stroma and striated muscle was seen, in the peptide-treated animals only mild reactive changes on the surface epithelium and scarce, unevenly distributed accumulations of polymorphonuclear inammatory cells on the muscle were noticed