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Protocol approach: post-surgical shoulder recovery Goal: Accelerate healing, reduce retear risk, optimize tissue quality Peptide approach: BPC-157: 300 to 500 mcg daily, starting as soon as cleared by surgeon (typically one to two weeks post-op) TB-500: 750 to 1000 mcg twice weekly GHK-Cu: 200 to 400 mcg daily from week three to four post-op Duration: Eight to sixteen weeks, aligned with surgical recovery timeline Critical notes: Any peptide use after surgery should be discussed with and approved by the operating surgeon

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Whole-cell current clamp recordings were made with a headstage (CV-7B) connected to a computer-controlled amplifier (MultiClamp 700B, Axon Instruments), digitized through a Digidata 1440A Analog/digital converter and acquired at a sampling rate of 10 kHz

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Persister Cell Derivation and Treatment Persister cells were derived from colorectal cancer cell lines HCT116 (KRAS G13D ) and SW620 (KRAS G12V ) treated with 5-FU and AZ628, for at least 9 days with fresh drug added every 3 days, and then stained with crystal violet or counted using a Countess Automated Cell Counter (Invitrogen, Carlsbad, CA, USA)