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Certain groupssuch as older adults, vegetarians, individuals with gastrointestinal disorders, and those taking specific medications (e.g., metformin or proton pump inhibitors)may develop a B12 deficiency

For C677T, the enzyme activity of heterozygous and homozygous mutant individuals are respectively 67 and 25% of the wild-type ones

Retrieved August 25, 2021

Frequency of dosing should be related to the severity of the deficiency

A big study in the Journal of Allergy and Clinical Immunology: In Practice confirmed these allergies are rare but real, and both types (cyanocobalamin and hydroxocobalamin) can trigger reactions

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