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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

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This may be an additional source of selection bias since some genital abnormalities such as varicocele may impact the outcome of AOX therapy of infertile men [36, 92]

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