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Serum metabolome analysis disclosed reduced GABA levels one year before seroconversion to insulin autoantibodies (IAA), but not before the appearance of GAD antibodies (120)

Hum Mol Genet 12:22772291

In the present study, we unveiled that methionine-derived SAM is exploited for the synthesis of UQ to maintain the integrity of mitochondrial respiratory chain, thereby methionine deprivation suppresses the accumulation of intracellular ROS that are released from electron transfer