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It is generally agreed that we have no evidence that febuxostat is a negative for the heart, just the question of the CARES trial as to whether it is not as protective as allopurinol

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10.3389/fbioe.2020.00213

Mov Disord Clin Pract 9:628636 Petersn A, Gil J, Maat-Schieman ML, Bjrkqvist M, Tanila H, Arajo IM, Smith R, Popovic N, Wierup N, Norln P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P (2005) Orexin loss in Huntingtons disease