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Nat Methods 9(7):676682

In line with our findings regarding the overexpression of genes regulated by SREBP2, recent data show that this pathway is critical for the development and tolerogenic function of regulatory DCs in the tumor microenvironment ( Given that cholesterol is important for DC homeostasis and function, we speculate that the observed changes in the expression of genes related to cholesterol metabolism in DCs may serve as a mechanism to modulate the immune response in favor of parasite survival

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