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The human body obtains glutathione in two ways: some is produced internally, while some is provided by the diet

An increased ratio of succinate to -KG in cancers resulting from impaired succinate dehydrogenase (SDH) activity is related to pervasive DNA hypermethylation, which contributes to the downregulation of key genes implicated in cell differentiation and cancer stages 102

10.1038/nature08768 8 Biyik-SitR.KruerT.DoughertyS.BradleyJ

DOI: 10.1016/S0006-291X(03)00810-6 10

The impact of ROS on tumor immunity TME is a key participant in tumor development, composed of cancer-associated fibroblasts (CAFs), various immune cells, endothelial cells, and the extracellular matrix (ECM) [134]