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The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway (Wang et al., 2020)

Ciura K, McBurney M, Nguyen B, Pham M, Rebueno N, Fuller CD, Guha-Thakurta N, Rosenthal DI

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It can increase IDO levels through the STAT3 pathway, thereby enhancing the significant immunosuppressive function of MDSCs [482, 483]

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