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Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats

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For example, in a myocardial reperfusion injury model, curcumin inhibits ferroptosis, autophagy, and apoptosis by upregulating HES1, effectively reducing tissue damage (172)

Surprisingly, there are possible combinations here with the enzyme component system (ECS) according to the invention (see below), ie the enzymatically generated dioxirane formation can be further increased

Since the level of -glutamyl-cysteine synthetase, the enzyme which is a rate limiting enzyme in the biochemical pathway of glutathione synthesis, is normal, the ratio stays high and induces a state of oxidative stress in the cells