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doi: 10.7554/eLife.58041 17 WakilSJAbu-ElheigaLA

In severe cases, can even cause blockages

Published 2017 Jun 28

Insufficient safety data

13:eabj0716

3.2 Metformin inhibits the TGF-1/Smad3 pathway Another mechanism of HSC activation is the cooperation of TGF-1-related signaling pathways and other signals, including ROS, PDGF, and connective tissue growth factors (66)