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Semi-quantitative histological analyses of the heart, bronchial mucosa, kidneys, and liver passive congestion (Table 1) were conducted according to previous descriptions (Chen et al., 2016

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To further simplify the three-component system, a chimeric crRNA-tracrRNA hybrid design was adapted, where a mature crRNA (comprising a guide sequence) is fused to a partial tracrRNA via a stem-loop to mimic the natural crRNA:tracrRNA duplex (Figure 3A)

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Supports research into fat reduction, lean muscle development, and tissue repair