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6:e00453

A paper titled "Oral Contraceptives: Effects on Folate and Vitamin B12 Metabolism"1 explains this issue in detail

Vitamin C doses ranging from 12.5g to 25g provide 500x the daily value, creating powerful antioxidant defenses

This suggests that the observed insulin secretory phenotype is relatively subtle and takes longer to manifest

Usually, the cell can remove reactive oxygen species (ROS) and reactive nitrogen species (RNS) through antioxidant molecules such as reduced glutathione (GSH) and primary defense enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione-dependent peroxidases (GPx) [1]