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Similarly, synergistic activity was observed between DEM and fluazinam, which has the same MoA with SYP-14288, and the SR value was highest at 40.50 in a 1:80 weight ratio

Notably, schlank, the drosophila CERS isoform, and mammalian CERS2 are capable of responding to intracellular fatty acid levels with direct binding and upregulation of Srebf expression and, conversely, downregulated expression of intracellular lipases (74, 75)

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