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Drug or alcohol use or withdrawal can also trigger symptoms in combination with other factors

doi: 10.5851/kosfa.2019.e81

Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): A multicentre, randomised, open-label, phase 3 trial

Begin within days of surgery continuing through rehabilitation phase (3-6 months typically)

The protein structures of these core targetsIL1B, IL6, TNF, AKT1, CASP3, MAPK3, BCL2, TGFB1, MMP9, and PPARGwere downloaded from the PDB database and docked with LC ligands accordingly