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These impacts encompass the diminution of dopaminergic neurons, the buildup of pathogenic proteins, and similar phenomena (573)

10.1371/journal.pone.0038019 PLoS ONE 36 IntaI.PaxianS.MaegeleI.ZhangW.PizziM.SpanoP.et al (2006)

Drugs that have a shorter half-life tend to act very quickly, but their effects wear off rapidly, meaning that they usually need to be administered several times a day intranasally to have the therapeutic effect