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Moreover, cyclooxygenase inhibitors, which suppress prostaglandin E2 synthesis, have been shown to reduce fungal biofilm formation, highlighting their potential as adjunctive agents in antifungal therapy ( 4.4 Antifungal drugs targeting metabolic pathways and enzymes Fungal metabolism involves a wide array of biochemical pathways essential for growth, survival, and virulence, including N-acetylglucosamine utilization, trehalose metabolism, lipid biosynthesis, energy production, and intracellular transport (Pan et al., 2018

Motawi TK, Darwish HA, Hamed MA, El-Rigal NS, Aboul Naser AF

Fe-dependent lipoxygenases then oxidize the latter to the toxic phospholipid hydroperoxide AA-OOH-PE

Bork, F

doi: 10.1016/j.redox.2017.11.001 191 SuiXZhangRLiuSDuanTZhaiLZhangMet al

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