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To date there is no complete understanding of the triggering pathomechanisms of disease, and no quantitative biomarker available with sufficient sensitivity, specificity, and adoptability to provide conclusive diagnosis

Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs

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After exogenous lactate intervention, primary VSMCs lost their contractile phenotype and differentiated into osteoblasts, accompanied by the increased opening rate of mitochondrial permeability transition pore, a significant decrease in MMP and mitochondrial energy generation capacity, and impaired mitochondrial biogenesis

10.1016/j.bbrc.2005.10.031 125

doi: 10.1080/07315724.2002.10719214