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Tonetti et al., 1990)

However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis

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Thorarensen, A

In an IBD context, one could speculate that during epithelial damage, sialylated glycoepitopes (especially those containing Neu5Ac) are exposed or shed, and eosinophils encountering these in the lamina propria via Siglec-8 may be signaled to undergo apoptosis

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