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The mitochondria are central to energy production in all cells and are affected by iron overload, leading to mitochondrial oxidative stress and participation in ferroptosis ( Recent studies have highlighted the role of mitochondrial calcium uniporters (MCU) in mediating iron-induced mitochondrial dysfunction

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Recent work has identified the endocannabinoid system (ECS) as a key mediator in lipotoxicity, with Cannabinoid receptor type 1 (CB1) activation promoting lipogenesis and inflammation (211)