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10.1212/wnl.55.11.1752 Neurology 43 FarahM

Embo J 36 , 13021315, (2017)

If a loss of melanin is a keystone of symptoms in neurodegenerative disease, then increasing melanin may provide a novel treatment

High levels of NAC (n-acetylcysteine) supplementation have been shown to temporarily reduce homocysteine levels.[ref] Excessive supplementation with B6, methylfolate, or betaine may cause homocysteine levels to trend to the low side in some people, but this isnt well documented in research studies