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10.1016/j.neubiorev.2018.05.005 56 JacksonL.EldahshanW.FaganS

The roles of different classes of hormones, growth factors, and cytokines in this multi-step process have been well demonstrated

Key causes include dehydration, nutrient-poor heme-rich diets, and substances like alcohol, tobacco, and certain medications that impair blood flow and accelerate cellular aging

The detrimental effects of social jetlag have been explained by the hypothalamic-pituitary-adrenal axis disruption and the influence of sleep architecture, incretin hormones, and mood [142,143]