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Description

Under hypoxic conditions, mitochondria produce more ROS

Key distinction: the licensed evidence concerns a defined afamelanotide implant

Excessive mitochondrial Ca 2+ uptake or impaired efflux promotes ROS generation and membrane potential dissipation, culminating in neuronal apoptosis 91

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In most forms of lentigo, there is a mildly increased number of melanocytes in the basal layer of the epidermis and variable elongation of the rete ridges