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The (i) initiation stage of tumorigenesis is characterized by increased production of peroxinitrite (ONOO ), superoxide (O 2 ) and hydroxyl ( OH) radicals and hydrogen peroxide (H 2 O 2 ) to accomplish the genetic alterations necessary for independent cellular proliferation

Think about the example mentioned earlier relating to autism and carnitine deficiencies: the outcome of something like a gut infection or antibiotic use, can alter intestinal bacterial populations (in this case, increased propionic acid causing a carnitine deficiency)