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Age-related declines in eNOS expression and functionality, together with the heightened oxidative degradation of NO by superoxide, undermine these advantageous effects, resulting in metabolic rigidity and muscle atrophy (19)

There is considerable regional and cell type variability of glutamate transporters.Cerebellar astrocytes have similar K m values for glutamate uptake relative to other brain regions (~50 M), however the Vmax of these astrocytes is the lowest of all brain regions studied (2.2 nmol/min/mg protein vs