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Current EPA Guidelines Require Updated Uncertainty Factors The guidelines on risk assessment of neurotoxic agents (EPA 1998) clearly indicate that an uncertainty factor of ten should be applied when attempting to extrapolate a lowest-observed adverse-effect-level (LOAEL) to establish an REL, as is the case for studies of mercury vapor toxicity the threshold cannot be determined from available studies

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Lancaster JM, Powell CB, Kauff ND, et al

doi: 10.1038/s41568-021-00435-0 19 BattagliaAMChirilloRAversaISaccoACostanzoFBiamonteF

Essential oil from Fructus Alpinia zerumbet ameliorates atherosclerosis by activating PPAR-LXR-ABCA1/G1 signaling pathway