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Without standardized fill, the dose drawn into the syringe varies between vials and even within the same vial

The principle of using mAbs to increase IgG catabolism was also demonstrated in NHPs, when Nixon and colleagues at Dyax Corp used phage-display selected human IgG1 mAbs with high pH-independent affinity towards FcRn to reduce circulatory IgG without affecting albumin levels in NHPs [122]

Similarly, examining how acute and/or repeated applications of neuropeptides affect expression of mucins (e.g., muc5AC, muc5B) in asthma, COPD, and CF would reveal a potentially causative role for neuropeptides in airway mucus phenotypes

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