eloralintide vs cagrilintide ADA2025: Cagri in Rats 🐀 Selective amylin mimetic shows improved tolerability and lean mass preservation 🧪 Preclinical head-to-head in lean & DIO rats 📉 Eloralintide: • Similar weight loss to Cagrilintide is an amylin analogue

Longer holds at each dose tier (6 weeks instead of 4) often produce better outcomes because the higher volume of distribution needs more time to reach steady state at each level

Grivennikov IA, et al

Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases

Within minutes of administration, changes occur in Akt1, VEGFR2, and eNOS expression

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The votes arent binding and the FDA has periodically bucked the recommendations of its outside experts