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Cuevasanta, E., Moller, M

10.1007/s11357-023-00861-y 121 PiJ.HayesJ

The therapy effectiveness is rooted in its capacity to promote neovascularization and immunoregulation, both pivotal for repairing hypoxic-ischaemic necrosis in the femoral head [1, 47]

As individuals age, there is a decline in the activity of the GH/IGF-1 axis, leading to lower IGF-1 concentrations and diminished functionality of the IGF-1 signaling pathway (35)

For example, the excessive activation of ferritinophagy, lipophagy, clock autophagy, and CMA can promote ferroptosis by degrading iron proteins, lipid droplets, circadian rhythm regulators, and GPX4, respectively (Honma et al., 2023

The mass effect of the hematoma significantly increases intracranial pressure, compressing surrounding brain tissue and neural tracts, potentially leading to brain herniation (Wilkinson et al., 2018)