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PubMed , JAMA Psychiatry , vol

Lazzeri L, Di Giovanni A, Exacoustos C, Tosti C, Pinzauti S, Malzoni M, et al

Other investigational compounds like acamprosate, neramexane, and AM-101 have also shown promise in clinical trials, though none are yet approved, highlighting the ongoing research need (Che et al., 2025)