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For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

10.3390/ijms25147676 Int J Mol Sci

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(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

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Particular emphasis is placed on the gut-brain axis, mitochondrial function, and epigenetic regulation as critical pathways through which nutrition impacts mental health