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Researchers who rush the escalation tend to experience more severe nausea, which can lead to skipped doses, inconsistent protocols, and ultimately worse outcomes

10.1038/s41385-022-00577-w

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Experiments showed that knocking down FTO in adult hippocampal neurons induced depression-like behavior, while overexpressing FTO reversed such behavior in response to unpredictable chronic mild stress

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There are numerous signaling and scaffolding proteins which are implicated in normal development and GABA synapse function