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The same was found in another study where increased lipid peroxidation and low-density lipoprotein oxidation were observed in the brains of hyperlipidemic mice and this was associated with increased activation of calpain-1/2 and MMP-2/9, and the downregulation of the TJs protein occludin in cerebral microvessels ( The intake of high doses of polyunsaturated fatty acids can promote lipid peroxidation and the subsequent propagation of oxygen radicals

Interestingly, the study also noted striking sex-based differences

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Xin et al found that the nuclear factor erythroid 2-related factor 2-heme oxygenase-1/glutathione peroxidase 4 axis in DM-associated ED rats was inhibited, leading to ferroptosis and oxidative stress, which impaired endothelial/smooth muscle cell function and further aggravated cavernous fibrosis [92]

Tight clothing around the abdomen creates similar pressure effects to excess weight

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