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10.1016/j.cub.2014.07.034 37 DaiW.XuY.MoS.LiQ.YuJ.WangR.et al (2020)

neurodegeneration can stimulate further inflammatory activity, resulting in further neuronal damage and death

Research has demonstrated that AGEs can trigger cellular senescence via several mechanisms, including the initiation of p21 in an oxidative stress-dependent manner, upregulation of p16 expression, inhibition of autophagy by diminishing PINK1/Parkin activity, and the promotion of inflammation in renal cells (Liu et al., 2014