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Notably, we identified that simultaneous targeting of glutamine synthesis and glutaminolysis could potently kill these mutants, suggesting a high dependency of KRAS mutant cells on nitrogen recycling and a possible new venue for therapeutic intervention

Role of Choline in Ocular Diseases

A high-fat diet-fed rat model was treated for 12 weeks with swertiamarin, ( R )-gentiandiol, ( S )-gentiandiol and silybin, and the therapeutic effects on non-alcoholic fatty liver disease (NAFLD) were systematically evaluated through biochemical indices and histopathological observations

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Investigation of possible effects of apigenin, sorafenib and combined applications on apoptosis and cell cycle in hepatocellular cancer cells

2010 Feb 3;7:8