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Cognitive disturbances in the cuprizone model of multiple sclerosis

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M.HassU.DalgaardM.AndersenH

Qiu QS, Guo Y, Quintero FJ, Pardo JM, Schumaker KS, Zhu JK

In biochemical assays, an SCF E3 ligase complex containing Fbxo40 directly ubiquitinates IRS1, and this activity is enhanced by increased tyrosine phosphorylation of IRS1