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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

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for standardizing the method used to measure glutathione levels and Luigi Cubeddu M.D., Ph.D

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In Arabidopsis , GSH1 is redox-activated by formation of an intra-molecular disulfide bridge between Cys 186 and Cys 406 [98]