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It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design

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doi: 10.1016/j.joca.2021.02.556 149 AkhtarNMet al

Inouye et al., 1985

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[DOI] [PubMed] [Google Scholar] Griego S.D., Weston C.B., Adams J.L., Tal-Singer R., Dillon S.B