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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

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doi: 10.1074/jbc.C000588200

however, these differences were not statistically significant (NCT03732586) [58]