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The insertion of four repeats of the antihypertensive dipeptide Val-Tyr into the hypervariable region of the 11S globulin acid subunit resulted in a recombinant protein with ACE inhibitory activity measured as eight times greater than that of the unmodified, native 11S globulin (Luna-Surez et al., 2010)

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The formation of Gla proteins allows the 2 positive charges of calcium to bind between the 2 negative charges on the carboxylic acid groups (COO-) in the Gla

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found that resveratrol alleviates excessive mitochondrial fission and promotes mitochondrial fusion in TGF-1-treated mesangial cells ( via inhibiting mitochondrial fission and promoting mitochondrial fusion in cisplatin-induced kidney injury ( 3.4.2 Nrf2 activators Studies have demonstrated that Nrf2-ARE signaling pathway also plays a core role in the regulation of mitochondrial dynamics