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The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

GraphPad Prism 10.0.0 software (GraphPad Software, La Jolla, CA) was used to produce graphs and perform the statistical analyses

These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels

We demonstrate that high levels of mut-p53, through binding to NRF2 and impairing its canonical antioxidant activities, directly promote ROS accumulation in cancer cells

There is some evidence that it could be useful for early diagnosis as well

150 L of PB buffer and 48 L of proxy matrix and 2 L of 0.001 mol/L of standard solution of the tested analytes were mixed