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Cohen OS, Chapman J, Korczyn AD, Nitsan Z, Appel S, Kahana E, Rosenmann H, Hoffmann C (2019) Disease duration in E200K familial CreutzfeldtJakob disease is correlated with clinical, radiological, and laboratory variables

This leads to elevated expression of cytokines such as IL-1, IL-6, and TNF-, fostering a chronic inflammatory milieu that hinders tissue resolution and favors fibrosis (Palma et al., 2024