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Moreover, Mn decreased REST expression in astrocytes, while overexpression of astrocytic REST exerted protection against Mn-induced neuronal cell toxicity by regulating inflammatory cytokines and glutamate transporter GLT-1/EAAT2 in astrocytes (Pajarillo et al., 2021)

CIT, classified as a non-essential amino acid and a precursor to L-arginine, has been shown to facilitate the production of NO and promote vasodilation, consequently enhancing endothelial functionality and muscle perfusion (911)

Narcan removes opioids from receptors in the central nervous system and replaces the opioids without activating the receptor

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The antioxidant effects of vitamin C and curcumin have been investigated in suppressing PIPN with demonstrated benefits in the reduction of TNF and IL6 levels in the DRG of rats [23, 24]