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The refined subtrees were midpoint-rooted using FastRoot [58], and tips were initially clustered using TreeCluster v1.0.4 (branch length threshold = 0.02, single linkage) [59]

Interfaces 8 , 2569125701 (2016)

Levodopa is regarded as the gold standard for PD treatment, effectively alleviating motor symptoms (Calabresi and Standaert, 2019)

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It has been proposed that histones provide a large reservoir of acetyl-units that can be mobilized either under metabolic stress or for a ready source of acetyl-CoA for site-specific histone acetylation and gene regulation 23,46,47