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Exploring chemoresistance and metastization potential mitigation strategies with combinatorial approaches with other drugs (such as ATRA) may also improve outcomes in the clinical setting

10.7717/peerj.2584 30 SalminenS.ColladoM

The research was supported in part by the National Institute of General Medical Sciences (R35GM127045 awarded to S.L.S.), the NCIs Cancer Target Discovery and Development (CTD^2) Network (grant number U01CA217848 and U01CA272612 awarded to S.L.S.), and by the NIBR Scholars Program

Innovative new sensors, such as a recently developed crowding sensor for osmolarity (Cuevas-Velazquez et al., Reference Cuevas-Velazquez, Vellosillo, Guadalupe, Schmidt, Yu, Moses, Brophy, Cosio-Acosta, Das, Wang, Jones, Covarrubias, Sukenik and Dinneny2021), will allow the experimental integration of stress responses, biomechanics and gene expression

TNF- treatment, for instance, causes sustained downregulation of GPX4, rendering cells more susceptible to ferroptosis [166]

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