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Researchers studied MRI brain scans of 22 Huntingtons patients, 9 controls, and images of human tissue from deceased Huntingtons patients

Significant declines in BDNF expression have been seen in several neurodegenerative diseases [58-60] and BDNF has been implicated as important in Alzheimers [61] and Huntingtons diseases [62]

Invoked mechanisms include modulation of osteoblastic and osteoclastic activity as well as stimulation of mesenchymal stem cell differentiation toward the chondrogenic lineage