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1 Regular use of H2RAs may lead to tachyphylaxis or tolerance, which can be prevented by intermittent use

10.7554/eLife.62852 64 ZhangJ.KeenanC.WangJ

Collectively, these investigations underscore luteolin as a promising multi-target therapeutic candidate for the treatment of AD, with the potential to alleviate neuroinflammation, oxidative stress, amyloid and tau pathology, and neuronal dysfunction