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First, our study was a single-arm study without a control group

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

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Indeed, sulfasalazine (which inhibits SLC7A11) effectively suppresses the proliferation of glutamine-depleted TNBC in vitro and in vivo 60

However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)

2025a;12:e06150