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Pharmacological therapeutics in Friedreich ataxia: the present state

Patients received daily doses of ubiquinol (50100 mg), vitamin E (30-60 mg), and B-group vitamins for at least 3 months

doi: 10.3390/life12122101 Summary Keywords interstitial lung disease, systemic sclerosis, cyclophosphamide, rituximab, mycophenolate mofetil, tocilizumab, nintedanib, pirfenidone Citation Kamenova A, Tzouvelekis A and Margaritopoulos GA (2023) Recent advances in the treatment of systemic sclerosis associated interstitial lung disease

Contrary to this expectation, recent studies have revealed an unexpected proferroptotic role for complex II

Briefly, mice exhibiting the FUSALS phenotype (characterized by FUS translocation from the nucleus to the cytoplasm) demonstrated longer lifespan, reduced disease severity and improved histological patterns when intracellular HSPA1A was overexpressed (Piavchenko et al., 2024