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In addition, the mechanism of detoxification by GSTD2 was revealed via its strong affinity towards isothiocyanate and catalysis of the conjugation between GSH and isothiocyanate

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Multiple human, animal, and cellular studies converge on the view that mitochondrial dysfunction, oxidative stress, and impaired mitophagy lead to leakage of mtDNA into the cytosol and extracellular space, where it activates innate immune sensors and sustains chronic inflammation

10.1016/j.biopha.2022.112836 45 YuX.GaoF.LiW.ZhouL.LiuW.LiM